PAXgene Tissue is a new, crosslinking-free, tissue-fixation technology to enable both molecular and traditional pathology testing. It simultaneously stabilizes molecular content and preserves morphology. Tissue samples fixed and stored in PAXgene Tissue Containers can be paraffin-embedded and used for pathology studies as well as for subsequent purification of RNA, miRNA, and/or DNA. The PAXgene Tissue RNA Kit provodes purification of total RNA from tissues fixed and stabilized in PAXgene Tissue Containers. Purification is carried out using silica-based RNA purification technology in a spin-column format. Used with the containers, the kit provides a complete preanalytical solution for collection, fixation, and stabilization through to purification of high-quality RNA for molecular analysis. The procedures can be fully automated on the QIAcube.