Genotyping and other DNA analyses using PCR or next-generation sequencing (NGS) require a suitable amount of high-quality genomic DNA as starting material. The most common bottleneck to obtaining high-quality DNA is tissue lysis. Fibrous or other hard-to-lyse tissues require lengthy and tedious protocols that often result in low yields of low-quality DNA. The QIAamp Fast DNA Tissue Kit, based on proven QIAGEN technologies, overcomes this bottleneck by providing innovative disruption tubes that significantly improve yield and shorten the overall time to result. The procedure can be fully automated on the QIAcube.