The GeneRead DNA FFPE Kit enables purification of high-quality genomic DNA (gDNA) from formalin-fixed paraffin embedded (FFPE) tissue samples using an optimized silica spin-column–based protocol. Artificial C>T mutations caused by cytosine deamination are critical in next-generation sequencing (NGS). These artifacts are caused by formalin fixation and aging, and result in sequencing errors. The GeneRead FFPE purification procedure also includes enzymatic removal of these artifacts, while ensuring high yields and purity, making it especially suitable for NGS applications.