Product Category : RNA / RNA / RNA Synthesis
Company/Manufacturer :
New England Biolabs
G(5′)ppp(5′)G RNA Cap Structure Analog
Product Category : RNA / RNA / RNA Synthesis
Company/Manufacturer :
New England Biolabs

The 5´ terminal m7G cap present on most eukaryotic mRNAs promotes translation in vitro at the initiation level (1,2,3). For most RNAs, elimination of the cap structure causes a loss of stability, especially against exonuclease degradation (4), and a decrease in the formation of the initiation complex of mRNAs for protein synthesis (4,5). Certain prokaryotic mRNAs containing a 5´ terminal cap structure are translated as efficiently as or more efficiently than eukaryotic mRNAs in a eukaryotic cell-free protein synthesizing system (5). Also a cap requirement has been observed for splicing eukaryotic substrate RNAs (6).

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