The RNeasy PowerClean Pro CleanUp Kit is the only commercially available kit to purify previously isolated RNA. The kit works well on RNA isolated from virtually any sample source, including problematic soils, samples spiked with commercial humic acids, as well as archived and previously isolated RNA samples.

PCR-inhibiting substances may discolor starting RNA an amber to brown color, indicating the presence of humics or polyphenols, although some inhibitors are colorless. The RNeasy PowerClean Pro CleanUp Kit will remove all colors and inhibitors including heme, polysaccharides, polyphenols, fluvic acids and dyes, leaving only RNA of the highest purity. Pure RNA is then ready for successful RT-PCR amplification and other downstream applications.

The backbone of the kit is the Inhibitor Removal Technology, which selectively removes inhibitors from the RNA solution. RNA is captured on a silica spin column membrane to be washed and eluted.

The RNeasy PowerClean Pro CleanUp Kit was previously sold by MO BIO as the PowerClean Pro RNA Cleanup Kit.